Zoloft is a pill that you will take orally, just once a day. You will notice the effects of Zoloft over the course of a few days as the medication works with your body to enhance your mood. Zoloft effects will not be noticeable just over night. Zoloft is a prescription that is to be used by adults only. Women who are pregnant or nursing should not take Zoloft prescriptions. Zoloft medications can make some users feel a bit tired, while other users will not feel this effect at all. Never take more than one dose at a time as this is not going to change your outlook any faster.