Prescribers should assess the patient's motivation to quit. Smoking cessation therapies are more likely to succeed in those patients whom are motivated to quit and have motivational support.

Zyban tablets should be swallowed whole and not crushed or chewed.

Patients should be treated for 7-9 weeks.

Although discontinuation reactions are not expected with Zyban, a tapering-off period may be considered.

If at seven weeks no effect is seen, treatment should be discontinued.

Use in Adults

It is recommended that treatment is started while the patient is still smoking and a "target stop date" set within the first two weeks of treatment with Zyban, preferably in the second week.

The initial dose is 150mg to be taken daily for six days, increasing on day seven to 150mg twice daily.

There should be an interval of at least 8 hours between successive doses.

The maximum single dose must not exceed 150mg and the maximum total daily dose must not exceed 300mg.

Insomnia is a very common adverse event which can be reduced by avoiding bedtime doses of Zyban (provided there is at least 8 hours between doses).

Use in Children and Adolescents

Use in patients under 18 years of age is not recommended as the safety and efficacy of Zyban tablets have not been evaluated in these patients.

Use in Elderly Patients

Zyban should be used with caution in elderly patients. Greater sensitivity in some elderly individuals cannot be ruled out. The recommended dose in the elderly is 150mg once a day.

Use in Patients with Hepatic Insufficiency

Zyban should be used with caution in patients with hepatic impairment. Because of increased variability in the pharmacokinetics in patients with mild to moderate impairment the recommended dose in these patients is 150mg once a day.

Use in Patients with Renal Insufficiency

Zyban should be used with caution in patients with renal insufficiency. The recommended dose in these patients is 150mg once a day.